• Stratacuity
  • $77,520.00 -128,560.00/year*
  • Cambridge , MA
  • Scientific Research
  • Full-Time
  • 101 Auburn St

Research Associate, Senior Research Associate, In Vivo 992602

Job Scope & Purpose:

Our Cambridge based client, focused in gene therapy, grounded in immune-oncology, is seeking an exceptional researcher to join their discovery team. In this role, you will be responsible for all in vivo studies testing a diversity of therapeutic compounds as single agents or in combination in mouse syngeneic and xenograft models for immuno-oncology drug and biomarker discovery, as well as patient selection strategies. You will independently perform tumor cell inoculations, administration of therapeutic agents via multiple routes, tumor measurements, survival, and overall animal health monitoring, tissue collection, and data recording. Depending on your experience and qualifications, the laboratory responsibilities could expand to ex vivo immune cell analyses and/or PK/PD biomarker analyses and offer the opportunity for growth. Apply now to learn more!

Primary Job Responsibilities:

  • Conduct exploratory and pre-clinical PK, PD and efficacy studies
  • Preparation of test articles and tumor cells for in vivo administration via multiple routes
  • Sub-cutaneous tumor cell inoculation and iv infusion of primary cells
  • In vivo dosing of mice via various routes (ip, iv, sc, and po)
  • Tumor growth measurements
  • Tissue harvesting (blood, tumor, lymph nodes, spleen, etc.)
  • Routine monitoring for health
  • Execute in vitro and ex vivo cell-based immunoassays to characterize the mechanism of action and activity of small molecule drugs designed to enhance anti-tumor immunity
  • Acquire/analyze data, report the data and troubleshoot for problems in experiments. Track and report study progress and status with oversight from a supervisor and/or project leader
  • Accurate documentation and outstanding data recording
  • Primary Job Requirements:

  • Minimum 2-4 years of directly relevant lab experience in an academic or industry setting
  • Exceptional in vivo experimental skills
  • Extensive experience with mouse syngeneic and xenograft tumor models, i.e., tumor cell inoculation, mouse dosing, tissue harvesting, tumor measurements
  • Proficiency in lab animal welfare and ability to precisely follow institutional procedures and protocols
  • Overall knowledge and strict compliance with federal and institutional guidelines for animal care and use
  • Hands-on experience in multiparameter flow cytometry, ex vivo primary/immune cell isolation and culture; experience in working with cell lines and human tissue/blood samples
  • Prior experience with any of the following assays is preferred: ELISA, Western blot, Luminex assay
  • Experience with tumor tissue processing and isolation of tumor-infiltrating immune cells
  • Flexibility in working schedule to accommodate weekend work
  • AALAS or LAT certification
  • Experience with minimally invasive surgical procedures
  • About Stratacuity:

    Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.

    PROVEN SCIENTIFIC PLACEMENT

    Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us.

    ...@stratacuity.com ...@stratacuity.com ...@stratacuity.com ...@stratacuity.com

    Code: DiscDevt

    EEO Employer

    Apex Systems is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at ...@apexsystemsinc.com or 844-###-####.


    Associated topics: aseptic technique, biopharmaceutical, diet, dietetic, dietician, immunoassay, pharmaceutical, pharmacometrics, protein, toxicologist

    * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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