The Monell Chemical Senses Center, founded in 1968, is the world s first nonprofit scientific institute devoted exclusively to basic research on the chemical senses: taste, smell, and chemosensory irritation. Research at Monell contributes to a wide range of scientific and practical knowledge. With more than fifty Ph.D.-level scientists, the Center is making major progress toward understanding how the chemical senses function and their importance in everyday life. The Center is located in the University City area of Philadelphia. For more information on Monell please visit our website at www.monell.org.
A Research Technician is currently available for research in the molecular mechanisms of taste stem cells and the signaling transduction of intestinal taste-like tuft cells (see recent representative publications) in the Jiang laboratory at the Monell Center.Experience with molecular biology and small animal surgery techniques is desired but not mandatory.A background in chemosensory research is not required.
Jiang P, Josue J, Li X, Glaser D, Li W, Brand JG, Margolskee RF, Reed DR, Beauchamp GK. (2012) Major taste loss in carnivorous mammals. Proc Natl Acad Sci USA. 109 (13): 4956-4961
Yee KK, Li Y, Redding KM, Iwatsuki K, Margolskee RF, Jiang P. (2013) Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue. Stem Cells. 31 (5): 992-1000.
Ren W, Lewandowski BC, Watson J, Iwatsuki K, Bachmanov AA, Margolskee RF, Jiang P (2014) Single Lgr5-or Lgr6-expressing taste stem cells generate taste bud cells ex vivo. Proc Natl Acad Sci USA. 111 (46): 16401-16406.
Lei W, Ren W, Ohmoto M, Urban JF, Matsumoto I, Margolskee RF, Jiang P (2018). Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc Natl Acad Sci USA.115(21):5552-5557.
Candidates should be proficient in the following:
A Ph.D. or an equivalent degree in molecular biology, genetics, neuroscience, immunology, physiology or a related field is required.
Experience with mouse handling is preferred.
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