• Crispr Therapeutics
  • $77,520.00 -128,560.00/year*
  • Cambridge , MA
  • Scientific Research
  • Full-Time
  • 101 Auburn St

Company Overview

At CRISPR Therapeutics, we are focused on developing transformative gene-based medicines for serious human diseases.

We are rapidly translating our specific, efficient and versatile CRISPR/Cas9 gene-editing platform into therapies to treat hemoglobinopathies, cancer, diabetes and other diseases

Our multi-disciplinary team of world-class researchers and drug developers works every day to translate our CRISPR/Cas9 technology into breakthrough human therapeutics. Our lead program targeting the blood diseases ?-thalassemia and sickle cell disease has entered clinical testing, and our immuno-oncology programs, focused on CRISPR/Cas9-edited allogeneic CAR-T cell therapies, have the potential to deliver a new generation of cancer therapies to patients.

Job Summary

We are seeking a Research Associate to join an exciting, fast-growing and well-financed company to develop novel gene editing therapies for serious diseases. The successful candidate will join the Technical Operations (Tech Ops) group at CRISPR Therapeutics, focusing on assay development of analytical methods for ex vivo genetically modified cells to support the development of gene editing programs. The individual will develop and run quantitative assays measuring process impurities in cell product. He or she will design, perform, and analyze experiments for multiple preclinical and clinical programs, and may assist in supporting process development, process characterization, product characterization, and technical transfer to CMOs and GMP test labs.

Responsibilities (ELISA and Assay Development)
  • Assist in the development and qualification of quantitative assays measuring process impurities
  • Perform routine analyses of samples to determine and report process impurity findings
  • Perform routine analyses of samples to determine and report cell-based potency assay findings
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  • Develop data sets supporting product specification and for qualification and/or validation of assays at CMOs and GMP test labs
  • Author technical reports on assay development/optimization and SOPs for assay performance
  • Analyze and present experimental data
  • Assess and implement new analytical technologies
  • Record results and data into Electronic Laboratory Notebook in an organized and timely manner
  • Minimum Qualifications (ELISA and Assay Development)
  • BS in life sciences and 2+ years of relevant experience
  • Hands-on experience in performing plate-based assays (ELISA, MSD, Luminex)
  • Scientifically rigorous, highly organized, and with significant attention to detail
  • Ability to work independently as well as collaborate with peers and effectively work in a results-oriented environment
  • Excellent oral and written communication skills
  • Preferred Qualifications (ELISA and Assay Development)
  • Experience with plate-based assay development
  • You may want to head home to start over, or reach out if you need further assistance.

  • Experience in analytical method development, qualification/validation
  • Experience in assay development for cell and gene therapy products
  • CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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    Associated topics: bacteria, biopharma, cytometry, drug discovery, food scientist, histotechnologist, immuno oncology, immunoassay, microbiology, pharmacy

    * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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