Research Assistant 4 (8295)


: $66,530.00 - $108,150.00 /year *

Employment Type

: Full-Time


: Scientific Research

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Working with high degree of independence and under general direction, the Research Assistant 4 will coordinate major activities of the laboratory and research staff. The research assistant will coordinate projects involving a critical cellular signaling system that controls T and B cell immune responses. This system was initially uncovered in immune cells, but it also underlies growth factor responses. Information gained from studies in specialized mice is verified in human cells and applied to human disorders. Clinical applications span autoimmunity, neuroscience, atherosclerosis, ophthalmology, and cancer. Focuses in immunology include Foxp3+ T regulatory cell (Treg) induction and B cell responses. Focuses in growth factor studies include vascular endothelial cell receptor (VEGFR2) signaling that controls angiogenesis and other growth factor receptor (RTK) signaling. The research assistant will function as a member of a lab in which the principal investigator directs an undergraduate immunology program in which Biology/Biochemistry students have their own projects. The research assistant will have exposure to many immunology and cell biology techniques and concepts through conducting the studies, reading, and working with the principal investigator and students. This position will work with animals.


  1. Coordinate major lab and research activities and staff. Coordinate research projects involving a critical cellular signaling system that controls T and B cell immune responses. Maintain schedules for staff, ensuring compliance with protocol guidelines and requirements of regulatory agencies; identify problems and/or inconsistencies and recommend corrective action as appropriate. Prepare IRB updates. (30%)
  2. Provide input and recommendations to principal investigator regarding significant developments in research projects (15%)
  3. Perform the most complex quantitative analytical procedures on data obtained from the research assistant s studies which include gene arrays and similar data sets. (15%)
  4. Carry out complex research assignments of a non-routine nature. Conduct studies in immunology and growth factor function. Techniques include mouse and human T and B cell isolations, flow cytometry, cell transfection, signaling mechanisms, flow cytometry Westerns, co-IPs, qPCR assays, ELISAs, primer design, ChIPs, in vivo studies in mice, bone marrow chimeras, adoptive transfer, lymph node and spleen isolation, immunization, analyses of patients T and B cells. (15%)
  5. Devise new protocols and techniques for research projects involving a high degree of skill and training. Evaluate adequacy of techniques; study and test new procedures and analyzes data. Coordinate information with others as needed. (6%)
  6. Co-author research projects. Present work at weekly lab meetings and critique presentations by others and students. (6%)
  7. May supervise Research Assistants and Technicians. Teach or instruct others in research techniques. (6%)

NonEssential Functions

Perform other duties as assigned. (<1%)


Department: Daily contact with supervisor and lab members to discuss research and maintain workflow.

University: Occasional contact with other departments to share information and collaborate on projects.

External: Limited or no contact with vendors to exchange information.

Students: Occasional contact with student employees to explain policies and procedures.


Will supervise research assistants and technicians.


Experience: 5 to 8 years of related experience required.

Education/Licensing: Bachelor s degree in science required.


  1. Has knowledge of commonly-used concepts, practices, and procedures within a particular field.
  2. Relies on instructions and pre-established guidelines to perform the functions of the job.
  3. Ability to operate laboratory equipment.
  4. Ability to meet consistent attendance.
  5. Ability to interact with colleagues, supervisors, and customers face to face.
  6. Strong molecular biology skills (PCR, Western blots, Retroviral/Lentiviral constructs).
  7. Strong organization skills and good habit of main training a clean lab working environment; demonstrate attention to detail and accuracy, time management skills, and proven ability to successfully follow-through on assigned projects.
  8. Professional and effective verbal and written communication skills and good interpersonal skills with the ability to work and communicate with various individuals within and external to the University.
  9. Ability to work effectively independently and collaboratively within a team (must be highly motivated, responsible, dependable and a self-starter).
  10. Ability to work with sensitive information and maintain confidentiality.
  11. Proficiency in Microsoft Office and GraphPad Prism is preferred. Experience using Adobe Photoshop, Illustrator, and FlowJo is a plus.
  12. Ability to maintain meticulous, complete, and easily retrievable laboratory data.
  13. Ability to willingly learn new techniques and procedures as needed, follow established protocols or laboratory procedures and request clarification if necessary.
  14. Must demonstrate compliance with university animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
  15. Must demonstrate compassion for animals within university facilities and dedication to the Animal Resource Center s mission. Must handle animals with care and respect at all times.
  16. Must be able and willing to learn new techniques, procedures, processes, and computer gear to protect the health of the animals.
  17. Previous experience working with animals preferred.
  18. Ability to meet consistent attendance.
  19. Ability to interact with colleagues, supervisors and customers face-to-face.


General laboratory environment. No radioactivity. The position will work with patient samples.

Case Western Reserve University's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the 'Guide for the Care and Use of Laboratory Animals appropriate Federal Animal Welfare Regulations, and the Public Health Service Policy on the Humane Care and Use of Laboratory Animals.' This position, and all animal research personnel, are subject to internal compliance to School of Medicine Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.

Associated topics: biopharma, drug development, histotechnologist, immunoassay, industrial hygienist, kinesiology, metabolism, nephrology, physiology, therapeutic * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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