• Broad Institute.
  • $94,410.00 -169,240.00/year*
  • Cambridge , MA
  • Scientific Research
  • Full-Time
  • 101 Auburn St

The Vector Engineering group at the Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT is looking for an exceptional candidate for a research associate position. The position provides the opportunity to join a new and rapidly expanding team focused on developing adeno-associated viruses (AAV) for efficient and targeted expression in the central nervous system.

The successful candidate will work closely with all members of the Vector Engineering team to support AAV vector cloning, AAV production and purification, and the development and implementation of quality control and standard operating procedures. The successful candidate will also contribute to collaborations with other Broad Institute scientists and teams, and will be expected to function independently in his/her daily responsibilities after training.

CHARACTERISTIC DUTIES

Work closely with team members to design, implement and troubleshoot experiments critical to the group s collective success

Work with team members to develop, plan and implement experiments and novel assays

Perform basic molecular biology such as plasmid construction, PCR, qPCR, and RNA and DNA extraction from tissue samples

Perform standard biochemical manipulations and analysis such as protein lysate preparation, western blotting, and immunoprecipitations

Perform tissue processing and immunohistochemistry

Produce, purify and assist in the evaluation of viral vectors for internal and collaborative projects

Consult colleagues and the scientific literature, as needed, to develop professional expertise and support ongoing and future projects

Troubleshoot to resolve problems and participate in new technology evaluation and implementation

Maintain meticulous records and document, compile, and analyze experimental data

Operate and maintain laboratory equipment and order and maintain stocks of reagents and supplies

Attend and present at team meetings to share results, plan projects and experiments, and ensure that projects support team goals

Interact and communicate with collaborators

Make contributions to scientific manuscripts and presentations

May perform other duties as assigned, including related lab management and reagent sharing

QUALIFICATIONS

B.S. or M.S. with 2+ years of research experience in a molecular or cellular biology environment preferably with hands-on experience with molecular biology, cell culture and viral vector production

Hands-on experience with molecular cloning, immunohistochemistry and production of viral vectors is strongly desired

Training with animal handling, colony maintenance and genotyping, and/or bioinformatics is also desired

Ability to think creatively and solve problems

Candidate should possess outstanding interpersonal and communication skills

Exceptional organizational and time management skills, lab notebook practices and careful attention to detail

Must be willing and able to develop and shift plans in service of a rapidly changing environment and troubleshoot to solve problems

The Broad Institute will not offerVisasponsorship for this opportunity. Foreign Nationals are encouraged to apply to Research Technician opportunities.


Associated topics: biochemistry, bioengineering, biology, biomedical engineer, bioprocessing, enzyme, hereditary, metabolic, pathogenesis, therapeutic

* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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