The Vector Engineering group at the Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT is looking for an exceptional candidate for a research associate position. The position provides the opportunity to join a new and rapidly expanding team focused on developing adeno-associated viruses (AAV) for efficient and targeted expression in the central nervous system.
The successful candidate will work closely with all members of the Vector Engineering team to support AAV vector cloning, AAV production and purification, and the development and implementation of quality control and standard operating procedures. The successful candidate will also contribute to collaborations with other Broad Institute scientists and teams, and will be expected to function independently in his/her daily responsibilities after training.
Work closely with team members to design, implement and troubleshoot experiments critical to the group s collective success
Work with team members to develop, plan and implement experiments and novel assays
Perform basic molecular biology such as plasmid construction, PCR, qPCR, and RNA and DNA extraction from tissue samples
Perform standard biochemical manipulations and analysis such as protein lysate preparation, western blotting, and immunoprecipitations
Perform tissue processing and immunohistochemistry
Produce, purify and assist in the evaluation of viral vectors for internal and collaborative projects
Consult colleagues and the scientific literature, as needed, to develop professional expertise and support ongoing and future projects
Troubleshoot to resolve problems and participate in new technology evaluation and implementation
Maintain meticulous records and document, compile, and analyze experimental data
Operate and maintain laboratory equipment and order and maintain stocks of reagents and supplies
Attend and present at team meetings to share results, plan projects and experiments, and ensure that projects support team goals
Interact and communicate with collaborators
Make contributions to scientific manuscripts and presentations
May perform other duties as assigned, including related lab management and reagent sharing
B.S. or M.S. with 2+ years of research experience in a molecular or cellular biology environment preferably with hands-on experience with molecular biology, cell culture and viral vector production
Hands-on experience with molecular cloning, immunohistochemistry and production of viral vectors is strongly desired
Training with animal handling, colony maintenance and genotyping, and/or bioinformatics is also desired
Ability to think creatively and solve problems
Candidate should possess outstanding interpersonal and communication skills
Exceptional organizational and time management skills, lab notebook practices and careful attention to detail
Must be willing and able to develop and shift plans in service of a rapidly changing environment and troubleshoot to solve problems
The Broad Institute will not offerVisasponsorship for this opportunity. Foreign Nationals are encouraged to apply to Research Technician opportunities.
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