Alnylam was founded in 2002 on a revolutionary vision and bold mission which remain firmly in place today. We are leading the translation of RNA interference (RNAi) into a new class of innovative medicines with the potential to transform the lives of people with rare genetic, cardio-metabolic, hepatic infectious, and central nervous system diseases with unmet need. ONPATTRO (patisiran), for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults, is Alnylams first U.S. FDA-approved RNAi therapeutic. In addition, Alnylam has three investigational medicines in late-stage development. Alnylam is proud to have been recognized as one of The Boston Globes Top Places to Work in 2015, 2016, 2017 and 2018.
We are currently seeking a passionate Associate Scientist with experience in small-animal surviving surgeries to join our dynamic, fast-paced and interdisciplinary team. Our mission is to drive the pre-clinical evaluation of siRNA-based therapeutics. The successful candidate will be technically skilled in animal research, be a well-rounded scientist and bring diverse technical and analytical approaches to biological analysis. Experience and passion for working with animals is a must.
Summary of Key Responsibilities
Design and execute studies to explore characterize molecules for RNAi therapeutic programs, including rodent disease models
Performin vivoprocedures, including administration of therapeutics via established methodologies and microsurgery techniques
Develop and conduct assays that supportin vivostudies (e.g. qPCR, ELISA) for the quantitative analysis of biomarkers or siRNA activity
Establish new methods for sample collection and analysis across indications
Utilize neuroscience assays and procedures
Identify biomarkers and validate bioanalytical assays
Performin vitroand cell-based assays to further characterize drug activity
Responsible for data entry and data analysis in timely manner
Prepare clearly articulated experimental reports and data presentations
Preparation of SOPs and animal protocols
Present data to groups within and outside of Research
The ideal candidate will have a BS or MS in Animal/veterinary studies, Cell/Molecular Biology, Biochemistry or related neuroscience field.
We require 3-5 years of research experience in an industrial or academic setting working with animals.
Experience in surviving surgeries and administration of anesthesia.
Excellent lab technique with the ability to analyze, interpret, and present data and work independently. Adherence to SOPs and familiarity with automation are critical.
The candidate must thrive in a team environment and possess excellent communication skills (both written and oral). The role requires strong interpersonal skills, the capacity to multi-task, and the ability to function across teams. We particularly seek someone who is detail oriented and who will flourish in a goal-driven team environment under tight deadlines.
Candidates must have experience in each of the following areas:
Familiarity with in vitro and in vivo assays for pharmacokinetic and pharmacodynamic evaluations.
Disease models and behavioral testing.
Purification and quantification of RNA/DNA/protein, including qPCR and ELISA; tissue culture experience a plus.
Experience within vivoneurophysiological characterization is preferred
Molecular biology and neuroscience experience preferred.